Liver Function Restores in Mice with Tiny 'Liver Buds'
A panel of researchers has published its latest study in the journal Nature1. The study has found that mice were able to restore their liver function when tiny 'liver buds' created from human stem cells were transplanted in them.
As per the findings, the liver buds were around 4 mm in size. These helped in delaying deaths in mice suffering from liver failure. A range of functions of liver, including producing human-specific metabolites and secreting liver-specific proteins, were confronted by the transplanted structures.
It was noted that the buds connected with close by blood vessels at a fast pace and then, continued to develop following transplantation. It is being said that the results were pilot, but these were effective at the same time.
Mount Sinai Hospital's Valerie Gouon-Evans from New York said that the host's blood system supported the liver buds. Thus, transplanted cells were able to proliferate, thereby performing liver functions.
The team has hopes that the findings could help in developing promising cures for many patients, who are in need of liver transplants each year.
"It's a great day for developmental biology. By reconstituting cell interactions that we know are important for natural liver progression, they get what appears to be robust, mature tissue", said Kenneth Zaret.
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